Generalized myasthenia gravis (gMG)
We're studying two different investigational treatments for gMG. They work in completely different ways, so some people qualify for one study but not the other. One prescreen covers both, and your coordinator helps match you to the study that fits.
Study 1 · oral, once-daily · Phase III
A 9-month study of an investigational oral, once-daily treatment that blocks a specific immune-system protein linked to gMG muscle weakness. It is compared with a placebo over a 6-month treatment phase, followed by follow-up visits.
You may be eligible if you
- Are between 18 and 85 years old
- Have a confirmed gMG diagnosis with positive AChR antibodies
- Have significant non-ocular symptoms, such as muscle weakness or fatigue
- Have been on a stable gMG treatment for at least 6 months (for example NSISTs, IVIG/PLEX, FcRn antagonists or rituximab)
Study timeline
Visit spacing is illustrative. Your coordinator gives you the exact schedule. A recent thymectomy (within 6 months), some recent treatments or an active infection may pause eligibility.
Study 2 · a different mechanism of action
A second investigational gMG treatment that works in a completely different way from Study 1. If you don't qualify for one study, you may still qualify for the other. Eligibility, the visit schedule and what the study involves are explained during your prescreen and coordinator call.


