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Understanding Amyloidosis

Amyloidosis Clinical Trials

Amyloidosis is a rare disease that occurs when abnormal proteins, called amyloids, build up in organs and tissues, disrupting their normal function. The type of amyloidosis and the organs affected determine the severity and progression of the disease. Early diagnosis and treatment are critical to managing symptoms and preventing complications.

Key Types of Amyloidosis:
  • AL (Primary) Amyloidosis: Caused by abnormal plasma cells in the bone marrow, often affecting the heart, kidneys, or liver.
  • AA (Secondary) Amyloidosis: Linked to chronic infections or inflammatory diseases.
  • Hereditary (ATTR) Amyloidosis: Caused by genetic mutations leading to abnormal transthyretin protein.
  • Wild-Type ATTR Amyloidosis: Affects older adults, commonly impacting the heart.
Key Symptoms of Amyloidosis:
  • Fatigue and weakness
  • Swelling in the ankles or legs
  • Shortness of breath
  • Numbness or tingling in hands and feet
  • Unexplained weight loss
  • Enlarged tongue or bruising around the eyes
What Causes Amyloidosis?
Amyloidosis develops when proteins fold abnormally and clump together, forming amyloid deposits in organs and tissues. These deposits can interfere with normal function, leading to symptoms. The causes vary by type:
  • AL Amyloidosis: Abnormal production of light chains by plasma cells.
  • AA Amyloidosis: Chronic inflammation or infections.
  • ATTR Amyloidosis: Genetic mutations or age-related changes in protein folding.

What Are Clinical Trials for Amyloidosis?

Clinical trials for amyloidosis are research studies that test new treatments, therapies, and diagnostic methods for this complex condition. The goals of these trials are to:
  • Develop targeted therapies to reduce amyloid deposits.
  • Improve early detection and diagnostic tools.
  • Explore gene therapies for hereditary forms of amyloidosis.
  • Enhance quality of life for patients with amyloidosis.
Why Participate in Amyloidosis Clinical Trials?
Participating in an amyloidosis clinical trial offers the opportunity to:
  • Access innovative treatments and therapies before they become publicly available.
  • Receive expert medical care and regular health evaluations.
  • Contribute to research that could improve outcomes for future patients.
  • Play a key role in advancing knowledge and treatment of amyloidosis.

Who Can Participate?

Eligibility criteria for amyloidosis clinical trials vary, but participants may include:
  • Individuals diagnosed with AL, AA, ATTR, or wild-type amyloidosis.
  • Patients experiencing organ dysfunction related to amyloidosis.
  • Individuals with a family history of hereditary amyloidosis.
  • Healthy individuals willing to serve as control participants.

Amyloidosis Clinical Trial – Do I Qualify?

Amyloidosis

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What to Expect During a Clinical Trial

Screening

Participants undergo a thorough evaluation to determine eligibility, including medical history review, genetic testing (if applicable), and organ function assessments.

Informed Consent

You’ll receive detailed information about the study’s purpose, procedures, potential risks, and benefits. Participation is voluntary, and you may withdraw at any time.

Participation

Participants may receive the investigational treatment, standard care, or a placebo. Regular medical visits, imaging tests, and lab work are conducted to monitor progress and outcomes.

Follow Ups

After completing the trial, participants are monitored for long-term outcomes and treatment effects.

How to Get Involved

  • Fill out the online registration form below.
  • Speak with our clinical trial coordinator to learn more about your eligibility.
  • Schedule a screening appointment.

Join Our Amyloidosis Clinical Trials Today

Your participation can help advance research and improve the lives of people living with amyloidosis. Together, we can work toward better treatments and hope for a cure.

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Frequently Asked Questions?

Amyloidosis is a condition where abnormal proteins, called amyloids, build up in organs and tissues, interfering with their normal function.

Eligibility varies by study but often includes patients diagnosed with amyloidosis or those with a family history of hereditary amyloidosis.

Yes, clinical trials are closely monitored and approved by ethics committees to ensure participant safety.

Some trials may offer compensation for travel and time, but participation is usually free.

Yes, participation is completely voluntary, and you may withdraw at any time.

Trial duration varies depending on the study but can range from a few months to several years.

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